Multiple Sclerosis Research Paper Outline

Functional MRI represents a powerful tool to detect task-related cortical activations and their changes potentially related to brain reorganization following MS damage, (RRMS) in November 2014.She was treated by interferon beta (Rebif 44), with a suboptimal response.The system is able to calibrate the working space according to patient's active mobility, and provides information about specific movement parameters.

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The subject performed repetitive finger opposition movements (thumb to index-middle-ring-little) with her right and left hand respectively for 180 consecutive seconds (60 active movements–60 resting state) at self-paced tone.

In addition she performed a bimanual task paced her movements with the tone of a metronome fixed at 2 Hz.

Once the UL was fitted to the system, the working space and the exercises were selected.

The working sessions were supervised by a skilled physiotherapist, who modified the exercise programs according to patient's progress. Data were acquired at 1 k Hz (National Instrument Board 800008B-01).

Our patient underwent a total of 40 1 hour-training sessions (i.e., 5 times a week for 8 consecutive weeks).

During the first session, the device was adjusted for patient's arm size and angle of suspension.

f MRI-sequences were build on block paradigm of 60 volumes (number of slice = 35, slice thickness = 5 mm; TR = 3000 ms; TE = 30 ms; field-of-view = 224 × 240 mm; matrix = 2 × 2 mm, duration = 3.09 minutes).

At T0 and T1, we acquired 3 f MRI run based on a block paradigm alternating 3 30 seconds task periods with 3 30 seconds rest periods.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited.

The work cannot be changed in any way or used commercially without permission from the journal.

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