Research Paper On Cystic Fibrosis

Research Paper On Cystic Fibrosis-33
Kerem’s study concluded with a PCR reaction with the F508 DNA flanked with specific mutant and normal oligonucleotides on either end.None of the newly synthesized DNA with the normal oligonucleotides had the TTT codon deletion.Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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This will bring new insights and perspectives in current advances in the field as well as provide managing approaches for this devastating disease. Venkateshwar Mutyam for his role in the conception and launch of this Research Topic.

Keywords: cystic fibrosis, CFTR, mutations, therapy development, therapeutic approches, drugs Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.

Once considered a childhood disease, over half of those living with CF in the United States are over the age of 18.

While life expectancy for those recently diagnosed has reached the mid-forties, the median age of death remains only thirty years.

Cystic fibrosis (CF) is a rare genetic, chronic, progressive disease that affects over 30,000 people in the United States, and over 70,000 people worldwide.

While most people associate cystic fibrosis with progressive lung disease, CF impacts the respiratory, digestive, reproductive, and endocrine systems.

Cystic Fibrosis was originally thought to be caused by bacterial infections alone, until the CF gene was discovered on human chromosome seven in 1989 (CF Foundation).

Early research led to the conclusion that CF was caused by a mutation in paroxonase, a series of enzymes that control the hydrolysis of organophosphates (Knight and Hodson, 1990).

Furthermore, several studies have focused on dissecting the mechanisms of action underlying these therapeutic approaches as well as understanding in depth the impact of mutations on CFTR structure and processing.

This Research Topic aims to gather a collection of reviews and original articles that provide novel information regarding the “Emerging Therapeutic Approaches for Cystic Fibrosis” at basic, translational and clinical levels.

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