The Olefin Metathesis Reaction Applications In The Pharmaceutical Industry

The Olefin Metathesis Reaction Applications In The Pharmaceutical Industry-46
Olefin Metathesis by Group VI (Mo, W) Metal Compounds, Alkenes, Reza Davarnejad and Baharak Sajjadi, Intech Open, DOI: 10.5772/intechopen.69320.

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Carbonyl-olefin metathesis reactions had been limited in scope, but this study demonstrates a catalyst and optimal reaction conditions that are generalizable for a variety of reactants opening the door for the synthesis of complex compounds. Iron(III)-catalysed carbonyl–olefin metathesis, Nature (2016). DOI: 10.1038/nature17432 Abstract The olefin metathesis reaction of two unsaturated substrates is one of the most powerful carbon–carbon-bond-forming reactions in organic chemistry.

The reaction is practically useful as iron is an earth-abundant metal and is environmentally safe, and the reactions are scalable. Specifically, the catalytic olefin metathesis reaction has led to profound developments in the synthesis of molecules relevant to the petroleum, materials, agricultural and pharmaceutical industries1.

One involves a two-step photochemical cycloaddition followed by a thermolysis cycloreversion.

Another involves a stoichiometric amount of transition-metal catalyst.

They also looked at the effects of incorporating a heteroatom, changing structural motifs, and changing the pendant isoprenyl group.

Overall, the Fe Cl catalyst showed remarkable versatility in the variety of reactions that were successfully completed.In general, they needed a catalyst that promotes [2 2] cycloaddition and [2 2] cyclorevrsion, does not promote side reactions such as polymerization or reforming reactants, and is chemoselective.They decided to investigate metal-derived Lewis acids. Schindler, Nature 533, 374–379 () doi:10.1038/nature17432 (Phys.org)—Olefin metathesis reactions where two allyls switch substituent groups, has proved to be a useful carbon-carbon bond forming reaction for drug discovery and other industrial processes. Furthermore, the catalyst uses iron, which is abundant and environmentally safe, and works under mild conditions for a variety of functional groups and at gram-level scales. Schindler of the University of Michigan have successfully found a Lewis acid catalyst that successfully exacts a carbonyl-olefin ring-closing metathesis reaction for the direct synthesis of functionalized carbocycles.Citation: Safe and generalizable catalyst for carbonyl-olefin metathesis reaction (2016, June 1) retrieved 7 September 2019 from https://phys.org/news/2016-06This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. Another reaction involves an organocatalyst that requires a cyclopropene reactant.All of these are limited in scope and, in the case of the photochemical reaction, require prohibitively harsh conditions.To date, no general protocol for catalytic carbonyl–olefin metathesis has been reported.Here we demonstrate a catalytic carbonyl–olefin ring-closing metathesis reaction that uses iron, an Earth-abundant and environmentally benign transition metal, as a catalyst.

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